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Co(III)-Catalyzed Enaminone-Directed C-H Amidation for Quinolone Synthesis

Pengfei Shi, Lili Wang, Kehao Chen, Jie Wang and Jin Zhu*

*School of Chemistry and Chemical Engineering, Collaborative Innovation Center of Chemistry for Life Sciences, Nanjing University, Nanjing 210023, China, Email: jinznju.edu.cn

P. Shi, L. Wang, K. Chen, J. Wang, J. Zhu, Org. Lett., 2017, 19, 2418-2421.

DOI: 10.1021/acs.orglett.7b00968 (free Supporting Information)


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Abstract

A Co(III)-catalyzed enaminone-directed C-H coupling with dioxazolones and subsequent deacylation of an installed amide group provides quinolones, an important heterocyclic scaffold for diverse pharmaceutically active structures.

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Co(III)-Catalyzed C-H-amidation



Key Words

quinolones


ID: J54-Y2017