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Synergistic Visible-Light Photoredox/Nickel-Catalyzed Synthesis of Aliphatic Ketones via N-C Cleavage of Imides

Javad Amani, Rauful Alam, Shorouk Badir and Gary A. Molander*

*Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, 231 South 34th Street, Philadelphia, Pennsylvania 19104-6323, United States, Email: gmolandrsas.upenn.edu

J. Amani, R. Alam, S. Badir, G. A. Molander, Org. Lett., 2017, 19, 2426-2429.

DOI: 10.1021/acs.orglett.7b00989 (free Supporting Information)


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Abstract

A visible-light-promoted photoredox/Ni-catalyzed cross-coupling reaction of imides with trifluoroborates provides aliphatic ketones. This operationally simple and mild cross-coupling reaction is performed at ambient temperature and exhibits tolerance for various functional groups.

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Key Words

acylation, photochemistry


ID: J54-Y2017