Synthesis of Substituted Cyclopropanecarboxylates via Room Temperature Palladium-Catalyzed α-Arylation of Reformatsky Reagents
Stephen N. Greszler*, Geoff T. Halvorsen and Eric A. Voight
*Centralized Lead Optimization - Discovery Chemistry & Technology, AbbVie, Inc., 1 N. Waukegan Road, North Chicago, Illinois 60064, United States, Email: stephen.greszlerabbvie.com
S. N. Greszler, G. T. Halvorsen, E. A. Voight, Org. Lett., 2017, 19, 2490-2493.
DOI: 10.1021/acs.orglett.7b00707 (free Supporting Information)
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A mild, room temperature palladium-catalyzed cross-coupling of aromatic and heteroaromatic halides with Reformatsky reagents derived from 1-bromocyclopropanecarboxylates provides α-arylated products. The method tolerates a broad range of functionalities and dramatically shortens many of the existing routes to access widely used 1,1-disubstituted cyclopropanecarboxylate derivatives.
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