Copper-Catalyzed Diaryl Ether Formation from (Hetero)aryl Halides at Low Catalytic Loadings
Yuntong Zhai, Xiaofei Chen, Wei Zhou, Mengyang Fan, Yisheng Lai and Dawei Ma*
*State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 200032, China, Email: madwsioc.ac.cn
Y. Zhai, X. Chen, W. Zhou, M. Fan, Y. Lai, D. Ma, J. Org. Chem., 2017, 82, 4964-4969.
Diaryl formation from phenols and (hetero)aryl halides is achieved in the presence of very low loadings of CuI and N,N'-bis(2-phenylphenyl) oxalamide (BPPO) or N-(2-phenylphenyl)-N'-benzyl oxalamide (PPBO) as ligands at 90°C using DMF or MeCN as the solvent.
see article for more examples
CuI/Oxalic Diamide Catalyzed Coupling Reaction of (Hetero)Aryl Chlorides and Amines
W. Zhou, M. Fan, J. Yin, Y. Jiang, D. Ma, J. Am. Chem. Soc., 2015, 137, 11942-11945.