Direct Regioselective Synthesis of Tetrazolium Salts by Activation of Secondary Amides under Mild Conditions
Veronica Tona, Boris Maryasin, Aurélien de la Torre, Josefine Sprachmann, Leticia González and Nuno Maulide*
*University of Vienna, Institute of Organic Chemistry, Währinger Strasse 38, 1090 Vienna, Austria,
Email: nuno.maulideunivie.ac.at
V. Tona, B. Maryasin, A. de la Torre, J. Sprachmann, L. González, N. Maulide, Org. Lett., 2017, 19, 2662-2665.
DOI: 10.1021/acs.orglett.7b01004
Abstract
A formal (3 + 2) cycloaddition enables a regioselective synthesis of biologically interesting tetrazolium salts employing simple amides and azides as starting materials. The mild conditions tolerate a broad range of functional groups.
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proposed mechanism
Key Words
ID: J54-Y2017