Catalytic Anti-Markovnikov Hydroallylation of Terminal and Functionalized Internal Alkynes: Synthesis of Skipped Dienes and Trisubstituted Alkenes
Melrose Mailig, Avijit Hazra, Megan K. Armstrong and Gojko Lalic*
*Department of Chemistry, University of Washington, Seattle, WA 98195, USA, Email: lalicchem.washington.edu
M. Mailig, A. Hazra, M. K. Armstrong, G. Lalic, J. Am. Chem. Soc., 2017, 139, 6969-6977.
DOI: 10.1021/jacs.7b02104 (free Supporting Information)
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The hydroallylation of terminal alkyl and aryl alkynes with simple allyl phosphates and 2-substituted allyl phosphates provides skipped dienes. The hydroallylation of functionalized internal alkynes enables the synthesis of complex trisubstituted alkenes.
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hydroallylation of an internal alkyne