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Rh-Catalyzed Anti-Markovnikov Hydrocyanation of Terminal Alkynes

Fei Ye, Junting Chen and Tobias Ritter*

*Max-Planck-Institut für Kohlenforschung, Kaiser-Wilhelm-Platz 1, 45470 Mülheim an der Ruhr, Germany, Email:

F. Ye, J. Chen, T. Ritter, J. Am. Chem. Soc., 2017, 139, 7184-7187.

DOI: 10.1021/jacs.7b03749


A highly stereo- and regioselective hydrocyanation of terminal alkynes provides E-configured alkenyl nitriles employing acetone cyanohydrin as a practical alternative to HCN gas. Acrylonitriles can be accessed on gram scale with broad substrate scope and functional group tolerance.

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Key Words

Vinyl Nitriles

ID: J48-Y2017