Rh-Catalyzed Anti-Markovnikov Hydrocyanation of Terminal Alkynes
Fei Ye, Junting Chen and Tobias Ritter*
*Max-Planck-Institut für Kohlenforschung,
Kaiser-Wilhelm-Platz 1, 45470 Mülheim an der Ruhr, Germany, Email: ritter
mpi-muelheim.mpg.de
F. Ye, J. Chen, T. Ritter, J. Am. Chem. Soc., 2017, 139, 7184-7187.
DOI: 10.1021/jacs.7b03749
Abstract
A highly stereo- and regioselective hydrocyanation of terminal alkynes provides E-configured alkenyl nitriles employing acetone cyanohydrin as a practical alternative to HCN gas. Acrylonitriles can be accessed on gram scale with broad substrate scope and functional group tolerance.
see article for more examples
Key Words
ID: J48-Y2017
