Synthesis of Functionalized Alkenes by a Transition-Metal-Free Zweifel Coupling
Roly J. Armstrong, Worawat Niwetmarin and Varinder K. Aggarwal*
*School of Chemistry, University of Bristol, Cantock's Close,
Bristol BS8 1TS, U.K.,
Email: v.aggarwal
bristol.ac.uk
R. J. Armstrong, W. Niwetmarin, V. K. Aggarwal, Org. Lett., 2017, 19, 2762-2765.
DOI: 10.1021/acs.orglett.7b01124
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Abstract
The Zweifel reaction is a powerful transition-metal-free alternative to the Suzuki-Miyaura reaction for the synthesis of alkenes. This transition-metal-free coupling process enables the coupling of Grignard reagents or organolithiums for an enantiospecific synthesis of a wide variety of functionalized acyclic and cyclic olefin products.
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mechanism of the Zweifel Olefination
Key Words
Zweifel Reaction, vinylation, arylation, iodine
ID: J54-Y2017
