Organic Chemistry Portal

Abstracts

Search:

Synthesis of Functionalized Alkenes by a Transition-Metal-Free Zweifel Coupling

Roly J. Armstrong, Worawat Niwetmarin and Varinder K. Aggarwal*

*School of Chemistry, University of Bristol, Cantock’s Close, Bristol BS8 1TS, U.K., Email: v.aggarwalbristol.ac.uk

R. J. Armstrong, W. Niwetmarin, V. K. Aggarwal, Org. Lett., 2017, 19, 2762-2765.

DOI: 10.1021/acs.orglett.7b01124 (free Supporting Information)



see article for more reactions

Abstract

The Zweifel reaction is a powerful transition-metal-free alternative to the Suzuki-Miyaura reaction for the synthesis of alkenes. This transition-metal-free coupling process enables the coupling of Grignard reagents or organolithiums for an enantiospecific synthesis of a wide variety of functionalized acyclic and cyclic olefin products.

see article for more examples

mechanism of the Zweifel Olefination



Key Words

Zweifel Reaction, vinylation, arylation, iodine


ID: J54-Y2017