Discovery of N-(Naphthalen-1-yl)-N'-alkyl Oxalamide Ligands Enables Cu-Catalyzed Aryl Amination with High Turnovers
Jie Gao, Subhajit Bhunia, Kailiang Wang, Lu Gan, Shanghua Xia and Dawei Ma*
*Interdisciplinary Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 26 Qiuyue Lu, Shanghai 201210, China, Email: madwsioc.ac.cn
J. Gao, S. Bhunia, K. Wang, L. Gan, S. Xia, D. Ma, Org. Lett., 2017, 19, 2809-2812.
DOI: 10.1021/acs.orglett.7b00901 (free Supporting Information)
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A class of N-(naphthalen-1-yl)-N'-alkyl oxalamides are powerful ligands in Cu-catalyzed coupling reactions of (hetero)aryl iodides and bromides with primary amines or ammonia. A wide range of coupling partners work well under these conditions.
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W. Zhou, M. Fan, J. Yin, Y. Jiang, D. Ma, J. Am. Chem. Soc., 2015, 137, 11942-11945.
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