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Trifluoromethylation of Secondary Nitroalkanes

Amber A. S. Gietter-Burch, Vijayarajan Devannah and Donald A. Watson*

*Department of Chemistry and Biochemistry, University of Delaware, Newark, Delaware 19716 United States, Email:

A. S. Gietter-Burch, V. Devannah, D. A. Watson, Org. Lett., 2017, 19, 2957-2960.

DOI: 10.1021/acs.orglett.7b01196

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The use of a commercially available Umemoto's reagent enables a metal-free trifluoromethylation of nitroalkanes. This method provides quaternary α-(trifluoromethyl)nitroalkanes, that can be elaborated to various complex nitrogen-containing molecules, including α-(trifluoromethyl)amines.

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Key Words

trifluoromethyl alkanes, α-trifluoromethyl amines, nitro compounds

ID: J54-Y2017