Trifluoromethylation of Secondary Nitroalkanes
Amber A. S. Gietter-Burch, Vijayarajan Devannah and Donald A. Watson*
*Department of Chemistry and Biochemistry, University of Delaware, Newark, Delaware 19716 United States, Email: dawatsonudel.edu
A. S. Gietter-Burch, V. Devannah, D. A. Watson, Org. Lett., 2017, 19, 2957-2960.
DOI: 10.1021/acs.orglett.7b01196 (free Supporting Information)
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The use of a commercially available Umemoto's reagent enables a metal-free trifluoromethylation of nitroalkanes. This method provides quaternary α-(trifluoromethyl)nitroalkanes, that can be elaborated to various complex nitrogen-containing molecules, including α-(trifluoromethyl)amines.
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