A Highly Efficient Copper-Catalyzed Three-Component Synthesis of 4-Aminoquinazolines
Lei Yang, Honghua Luo, Yan Sun, Zhenyu Shi, Kaidong Ni, Fei Li, Dongyin Chen*
*Department of Medicinal Chemistry, School of Pharmacy, Nanjing Medical University, Nanjing 211166, P. R. of China, Email: chendongyinnjmu.edu.cn
L. Yang, H. Luo, Y. Sun, Z. Shi, K. Ni, F. Li, D. Chen, Synthesis, 2017, 49, 2535-2543.
DOI: 10.1055/s-0036-1588727
Abstract
A highly efficient one-pot synthesis of 4-aminoquinazolines from easily available 2-iodo- or 2-bromobenzimidamides, aldehydes, and sodium azide proceeds via consecutive copper-catalyzed SNAr substitution, reduction, cyclization, oxidation and tautomerization.
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Key Words
copper, 2-halobenzimidamides, sodium azide, multicomponent reactions, catalysis, quinazolines, 4-aminoquinazolines
ID: J66-Y2017