Noncovalent Interactions in Ir-Catalyzed C-H Activation: L-Shaped Ligand for Para-Selective Borylation of Aromatic Esters
Md Emdadul Hoque, Ranjana Bisht, Chabush Haldar and Buddhadeb Chattopadhyay*
*Center of Bio-Medical Research, Division of Molecular Synthesis & Drug Discovery, SGPGIMS Campus, Raebareli Road, Lucknow 226014, Uttar Pradesh, India, Email: buddhadeb.ccbmr.res.in
M. E. Hoque, R. Bisht, C. Haldar, B. Chattopadhyay, J. Am. Chem. Soc., 2017, 139, 7745-7748.
DOI: 10.1021/jacs.7b04490 (free Supporting Information)
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For achieving high para-selectivity in the Ir-catalyzed borylation of aromatic esters, an L-shaped bipyridine ligand is essential to recognize the functionality of the oxygen atom of the ester carbonyl group via noncovalent interaction.
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proposed transition state