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Copper-Promoted Desulfitative N-Arylation of Sulfonamides and Sulfoximines with Sodium Arylsulfinates

Yangji Jiang, Yaping You, Wanrong Dong*, Zhihong Peng, Yingjun Zhang* and Delie An*

*College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, P. R. China, Email: wanrongdonghnu.edu.cn, ZhangYingjunhec.cn, delieanhnu.edu.cn

Y. Jiang, Y. You, W. Dong, Z. Peng, Y. Zhang, D. An, J. Org. Chem., 2017, 82, 5810-5818.

DOI: 10.1021/acs.joc.7b00633 (free Supporting Information)


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Abstract

A general and direct N-arylation of sulfonamides and NH-sulfoximines by sodium arylsulfinates through a desulfitative pathway proceeded with catalytic loadings of Cu(II) without any external ligands. This arylation protocol offers high efficiency and good substituent tolerance.

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proposed mechanism



Key Words

sulfonamides, sulfoximines


ID: J42-Y2017