Organic Chemistry Portal



Copper-Promoted Desulfitative N-Arylation of Sulfonamides and Sulfoximines with Sodium Arylsulfinates

Yangji Jiang, Yaping You, Wanrong Dong*, Zhihong Peng, Yingjun Zhang* and Delie An*

*College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, P. R. China, Email:,,

Y. Jiang, Y. You, W. Dong, Z. Peng, Y. Zhang, D. An, J. Org. Chem., 2017, 82, 5810-5818.

DOI: 10.1021/acs.joc.7b00633

see article for more reactions


A general and direct N-arylation of sulfonamides and NH-sulfoximines by sodium arylsulfinates through a desulfitative pathway proceeded with catalytic loadings of Cu(II) without any external ligands. This arylation protocol offers high efficiency and good substituent tolerance.

see article for more examples

proposed mechanism

Key Words

sulfonamides, sulfoximines

ID: J42-Y2017