Sonochemistry as a General Procedure for the Synthesis of Coumarins, Including Multigram Synthesis
Ligia S. da Silveira Pinto, Marcus V. N. de Souza*
*Universidade Federal do Rio de Janeiro, Instituto de Química, Departamento de Química Orgânica, CP 68563, 21945-970 Rio de Janeiro, Brazil, Email: marcos_souzafar.fiocruz.br
L. S. da Silveira Pinto, M. V. N. de Souza, Synthesis, 2017, 49, 2555-2561.
DOI: 10.1055/s-0036-1590201 (free Supporting Information)
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The application of sonochemistry for the synthesis of different coumarins from active methylene compounds and 2-hydroxybenzaldehydes or resorcinol was very effective on a multigram scale with a higher yield, higher amount of crystalline compound, and shorter reaction time compared with the compounds obtained using the classical procedures.
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