Organic Chemistry Portal



Reagent Design and Ligand Evolution for the Development of a Mild Copper-Catalyzed Hydroxylation Reaction

Patrick S. Fier* and Kevin M. Maloney*

*Department of Process Research and Development, Merck & Co., Inc., Rahway, New Jersey 07065, United States, Email:,

P. S. Fier, K. M. Maloney, Org. Lett., 2017, 19, 3033-3036.

DOI: 10.1021/acs.orglett.7b01403 (free Supporting Information)


A copper-catalyzed synthesis of phenols with a traceless hydroxide surrogate under mild reaction conditions enables even a late-stage functional group transformation of druglike substrates.

see article for more examples

proposed mechanism

Direct Conversion of Haloarenes to Phenols under Mild, Transition-Metal-Free Conditions

P. S. Fier, K. M. Maloney, Org. Lett., 2016, 18, 2244-2247.

Key Words


ID: J54-Y2017