Reagent Design and Ligand Evolution for the Development of a Mild Copper-Catalyzed Hydroxylation Reaction
Patrick S. Fier* and Kevin M. Maloney*
*Department of Process Research and Development, Merck & Co.,
Inc., Rahway, New Jersey 07065, United States, Email: patrick.fier
merck.com,
kevin_maloneymerck.com
P. S. Fier, K. M. Maloney, Org. Lett., 2017, 19, 3033-3036.
DOI: 10.1021/acs.orglett.7b01403
Abstract
A copper-catalyzed synthesis of phenols with a traceless hydroxide surrogate under mild reaction conditions enables even a late-stage functional group transformation of druglike substrates.
see article for more examples
proposed mechanism
Direct Conversion of Haloarenes to Phenols under Mild, Transition-Metal-Free Conditions
P. S. Fier, K. M. Maloney, Org. Lett., 2016, 18, 2244-2247.
Key Words
ID: J54-Y2017
