Copper-Catalyzed Asymmetric Hydroboration of 1,1-Disubstituted Alkenes
Zining Wang, Xiaxia He, Rui Zhang, Ge Zhang, Guoxing Xu, Qian Zhang, Tao Xiong* and Qian Zhang
*Jilin Province Key Laboratory of Organic Functional
Molecular Design & Synthesis, Department of Chemistry, Northeast Normal
University, Changchun 130024, China, Email: xiongt626
nenu.edu.cn
Z. Wang, X. He, R. Zhang, G. Zhang, G. Xu, Q. Zhang, T. Xiong, Q. Zhang, Org. Lett., 2017, 19, 3067-3070.
DOI: 10.1021/acs.orglett.7b01135
see article for more reactions
Abstract
A mild, efficient, highly regio- and enantioselective copper-catalyzed hydroboration of 1,1-diaryl substituted alkenes with bis(pinacolato)diboron provides a series of valuable β,β-diaryl substituted boronic esters with high enantiomeric purity. Moreover, this approach is also be suitable for hydroboration of α-alkyl styrenes for the synthesis of enantioenriched β,β-arylalkyl substituted boronic esters.
see article for more examples
Key Words
ID: J54-Y2017
