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Regio- and Stereospecific Copper-Catalyzed Substitution Reaction of Propargylic Ammonium Salts with Aryl Grignard Reagents

Manuel Guisán-Ceinos, Victor Martín-Heras and Mariola Tortosa*

*Departamento de Química Orgánica, Universidad Autónoma de Madrid, Cantoblanco, 28049 Madrid, Spain, Email: mariola.tortosauam.es

M. Guisán-Ceinos, V. Martín-Heras, M. Tortosa, J. Am. Chem. Soc., 2017, 139, 8448-8451.

DOI: 10.1021/jacs.7b05273


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Abstract

A copper-catalyzed substitution reaction of propargylic ammonium salts with aryl Grignard reagents is stereospecific and α-regioselective and proceeds with exceptional functional group tolerance.

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Key Words

propargylation


ID: J48-Y2017