Organic Chemistry Portal

Abstracts

Search:

Palladium-Catalyzed α-Arylation of Oxindoles

Matthew J. Durbin and Michael C. Willis*

*Department of Chemistry, University of Oxford, Chemical Research Laboratory, Mansfield Road, Oxford, OX1 3TA, United Kingdom, Email: michael.willischem.ox.ac.uk

M. J. Durbin, M. C. Willis, Org. Lett., 2008, 10, 1413-1415.

DOI: 10.1021/ol800141t (free Supporting Information)


Abstract

A catalyst generated from Pd(dba)2 and a bulky electron-rich phosphine ligand is effective for the α-arylation of oxindoles. Generation of the potassium-enolates of a range of oxindoles enables the coupling with aryl chlorides, bromides, and triflates.

see article for more examples



Key Words

oxindoles, α-arylation


ID: J54-Y2017