Organic Chemistry Portal



Palladium-Catalyzed α-Arylation of Oxindoles

Matthew J. Durbin and Michael C. Willis*

*Department of Chemistry, University of Oxford, Chemical Research Laboratory, Mansfield Road, Oxford, OX1 3TA, United Kingdom, Email:

M. J. Durbin, M. C. Willis, Org. Lett., 2008, 10, 1413-1415.

DOI: 10.1021/ol800141t


A catalyst generated from Pd(dba)2 and a bulky electron-rich phosphine ligand is effective for the α-arylation of oxindoles. Generation of the potassium-enolates of a range of oxindoles enables the coupling with aryl chlorides, bromides, and triflates.

see article for more examples

Key Words

oxindoles, α-arylation

ID: J54-Y2017