Palladium-Catalyzed α-Arylation of Oxindoles
Matthew J. Durbin and Michael C. Willis*
*Department of Chemistry, University of Oxford, Chemical
Research Laboratory, Mansfield Road, Oxford, OX1 3TA, United Kingdom,
Email: michael.willischem.ox.ac.uk
M. J. Durbin, M. C. Willis, Org. Lett., 2008, 10, 1413-1415.
DOI: 10.1021/ol800141t
Abstract
A catalyst generated from Pd(dba)2 and a bulky electron-rich phosphine ligand is effective for the α-arylation of oxindoles. Generation of the potassium-enolates of a range of oxindoles enables the coupling with aryl chlorides, bromides, and triflates.
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Key Words
ID: J54-Y2017