Organic Chemistry Portal



Dual Role of H2O2 in Palladium-Catalyzed Dioxygenation of Terminal Alkenes

Jiuzhong Huang, Jianxiao Li, Jia Zheng, Wanqing Wu*, Weigao Hu, Lu Ouyang and Huanfeng Jiang*

*School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510640, P. R. China, Email:,

J. Huang, J. Li, J. Zheng, W. Wu, W. Hu, L. Ouyang, H. Jiang, Org. Lett., 2017, 19, 3354-3357.

DOI: 10.1021/acs.orglett.7b01228

see article for more reactions


A palladium-catalyzed, environmentally friendly dioxygenation reaction of simple alkenes enables a rapid assembly of valuable α-hydroxy ketones with high atom economy.

see article for more examples

proposed mechanism

Key Words

α-hydroxy ketones, α-hydroxylation, hydrogen peroxide

ID: J54-Y2017