Dual Role of H₂O₂ in Palladium-Catalyzed Dioxygenation of Terminal Alkenes

Jiuzhong Huang, Jianxiao Li, Jia Zheng, Wanqing Wu*, Weigao Hu, Lu Ouyang and Huanfeng Jiang*

*School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510640, P. R. China, Email: cewuwqscut.edu.cn, jianghfscut.edu.cn

J. Huang, J. Li, J. Zheng, W. Wu, W. Hu, L. Ouyang, H. Jiang, Org. Lett., 2017, 19, 3354-3357.

DOI: 10.1021/acs.orglett.7b01228

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Abstract

A palladium-catalyzed, environmentally friendly dioxygenation reaction of simple alkenes enables a rapid assembly of valuable α-hydroxy ketones with high atom economy.

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proposed mechanism

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Key Words

α-hydroxy ketones, α-hydroxylation, hydrogen peroxide

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ID: J54-Y2017