In Situ Electrophilic Activation of Hydrogen Peroxide for Catalytic Asymmetric α-Hydroxylation of 3-Substituted Oxindoles
Kohsuke Ohmatsu, Yuichiro Ando, Takashi Ooi*
*Institute of Transformative Bio-Molecules (WPI-ITbM) and Department of Applied Chemistry, Graduate School of Engineering, Nagoya University, Nagoya 464-8601, Japan, Email: tooiapchem.nagoya-u.ac.jp
K. Ohmatsu, Y. Ando, T. Ooi, Synlett, 2017, 28, 1291-1294.
DOI: 10.1055/s-0036-1558958 (free Supporting Information)
Peroxy trichloroacetimidic acid, in situ generated from aqueous hydrogen peroxide and trichloroacetonitrile, acts as a competent electrophilic oxygenating agent for a direct enantioselective α-hydroxylation of oxindoles in the presence of a chiral 1,2,3-triazolium salt as a phase-transfer catalyst.
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