Transition-Metal-Free Homologative Cross-Coupling of Aldehydes and Ketones with Geminal Bis(boron) Compounds
Thomas C. Stephens and Graham Pattison*
*Department of Chemistry, University of Warwick, Gibbet Hill
Road, Coventry, CV4 7AL, U.K.,
Email: g.pattison
brighton.ac.uk
T. C. Stephens, G. Pattison, Org. Lett., 2017, 19, 3498-3501.
DOI: 10.1021/acs.orglett.7b01474 (free Supporting Information)
Abstract
A transition-metal-free coupling of aldehydes and ketones with geminal bis(boron) building blocks provides homologated carbonyl compounds upon oxidation. Aldehydes with an enolizable stereogenic center undergo this reaction with complete retention of stereochemistry.
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Key Words
carbonyl compounds (coupling, oxidation), sodiumperborate
ID: J54-Y2017
