Copper-Catalyzed Highly Efficient Esterification of Aldehydes with N-Hydroxyphthalimide via Cross-Dehydrogenative Coupling in Water at Room Temperature
Zhicheng Guo, Xinpeng Jiang, Can Jin*, Jiadi Zhou, Bin Sun, Weike Su*
*Zhejiang University of Technology, Hangzhou 310014, P. R. of China, Email: jincanzjut.edu.cn, pharmlabzjut.edu.cn
Z. Guo, X. Jiang, C. Jin, J. Zhou, B. Sun, W. Su, Synlett, 2017, 28, 1321-1326.
DOI: 10.1055/s-0036-1588760 (free Supporting Information)
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A copper-catalyzed cross-dehydrogenative coupling reaction between N-hydroxyphthalimide and aldehydes using PhI(OAc)2 as an oxidant enables a synthesis of NHPI esters in good yields in water. This facile and efficient method is eco-friendly and offers mild conditions, short reaction time, and broad substrate scope.
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