A Novel Route to 2-Arylquinolines: Reductive Cleavage of 2′-Nitroaryl-∆²-isoxazolines

Prashantha Kamath, Russell C. Viner, Stephen C. Smith, Mukul Lal*

*Syngenta Biosciences Pvt. Ltd., Santa Monica Works, Corlim, Ilhas, Goa-403110, India, Email: mukul.lalsyngenta.com

P. Kamath, R. C. Viner, S. C. Smith, M. Lal, Synlett, 2017, 28, 1341-1345.

DOI: 10.1055/s-0036-1588751

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Abstract

Quinolines can be synthesized from Δ²-isoxazolines under reductive conditions. The reductive cyclization to quinolines is achieved in the presence of iron or sodium dithionite under metal-free conditions.

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Key Words

heterocycles, cyclization, reduction, iron, isoxazoline, quinolines

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ID: J60-Y2017