A Novel Route to 2-Arylquinolines: Reductive Cleavage of 2′-Nitroaryl-∆2-isoxazolines
Prashantha Kamath, Russell C. Viner, Stephen C. Smith, Mukul Lal*
*Syngenta Biosciences Pvt. Ltd., Santa Monica Works, Corlim, Ilhas, Goa-403110, India, Email: mukul.lalsyngenta.com
P. Kamath, R. C. Viner, S. C. Smith, M. Lal, Synlett, 2017, 28, 1341-1345.
DOI: 10.1055/s-0036-1588751 (free Supporting Information)
see article for more reactions
Quinolines can be synthesized from Δ2-isoxazolines under reductive conditions. The reductive cyclization to quinolines is achieved in the presence of iron or sodium dithionite under metal-free conditions.
see article for more examples