Direct Conversion of Carboxylic Acids to Alkyl Ketones
Javad Amani and Gary A. Molander*
*Roy and Diana Vagelos Laboratories, Department of Chemistry,
University of Pennsylvania, 231 South 34th Street, Philadelphia, Pennsylvania
19104-6323, United States,
Email: gmolandr
sas.upenn.edu
J. Amani, G. A. Molander, Org. Lett., 2017, 19, 3612-3615.
DOI: 10.1021/acs.orglett.7b01588
see article for more reactions
Abstract
Synergistic, Ir-photoredox/nickel catalytic cross-coupling of in situ activated carboxylic acids and alkyltrifluoroborates enables an efficient and mild method for acyl-Csp3 bond formation. The cross-coupling protocol of structurally diverse carboxylic acids with various potassium alkyltrifluoroborates affords the corresponding aliphatic ketones with high yields in an operationally simple manner.
see article for more examples
proposed mechanism
Key Words
acylation, photochemistry
ID: J54-Y2017
