Direct Conversion of Carboxylic Acids to Alkyl Ketones
Javad Amani and Gary A. Molander*
*Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, 231 South 34th Street, Philadelphia, Pennsylvania 19104-6323, United States, Email: gmolandrsas.upenn.edu
J. Amani, G. A. Molander, Org. Lett., 2017, 19, 3612-3615.
DOI: 10.1021/acs.orglett.7b01588 (free Supporting Information)
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Synergistic, Ir-photoredox/nickel catalytic cross-coupling of in situ activated carboxylic acids and alkyltrifluoroborates enables an efficient and mild method for acyl-Csp3 bond formation. The cross-coupling protocol of structurally diverse carboxylic acids with various potassium alkyltrifluoroborates affords the corresponding aliphatic ketones with high yields in an operationally simple manner.
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