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Transfer Hydrogenation of Carbonyl Derivatives Catalyzed by an Inexpensive Phosphine-Free Manganese Precatalyst

Antoine Bruneau-Voisine, Ding Wang, Vincent Dorcet, Thierry Roisnel, Christophe Darcel and Jean-Baptiste Sortais*

*Institut des Sciences Chimiques de Rennes, UMR 6226 CNRS-Université de Rennes 1, 263 avenue du Général Leclerc, Rennes 35042 Cedex, France, Email: jean-baptiste.sortaislcc-toulouse.fr

A. Bruneau-Voisine, D. Wang, V. Dorcet, T. Roisnel, C. Darcel, J.-B. Sortais, Org. Lett., 2017, 19, 3656-3659.

DOI: 10.1021/acs.orglett.7b01657 (free Supporting Information)


Abstract

A very simple and inexpensive catalytic system based on abundant manganese as transition metal and on an inexpensive phosphine-free bidendate ligand enables the reduction of a broad range of carbonyl derivatives with 2-propanol as hydrogen donor at room temperature. The reaction runs with low catalyst loading and exhibits a good functional group tolerance.

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Key Words

Meerwein-Ponndorf-Verley Reduction, 2-Propanol


ID: J54-Y2017