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Ligand-Accelerated Gold-Catalyzed Addition of in Situ Generated Hydrazoic Acid to Alkynes under Neat Conditions

Xiaoqing Li, Shengrong Liao, Zhixun Wang and Liming Zhang*

*Department of Chemistry and Biochemistry, University of California, Santa Barbara, California 93106, United States, Email:

X. Li, S. Liao, Z. Wang, L. Zhang, Org. Lett., 2017, 19, 3687-3690.

DOI: 10.1021/acs.orglett.7b01359

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Low loadings of a gold catalyst derived from a functionalized biaryl-2-ylphosphine ligand (WangPhos) enable a direct addition of in situ generated hydrazoic acid to terminal as well as internal alkynes.

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Key Words

vinyl azides

ID: J54-Y2017