Alkyne Cycloadditions Mediated by Tetrabutylammonium Fluoride: A Unified and Diversifiable Route to Isoxazolines and Pyrazolines
Edith Nagy and Salvatore D. Lepore*
*Department of Chemistry and Biochemistry, Florida Atlantic University, Boca Raton, Florida 33431-0991, United States, Email: sleporefau.edu
E. Nagy, S. D. Lepore, Org. Lett., 2017, 19, 3695-3698.
DOI: 10.1021/acs.orglett.7b01401 (free Supporting Information)
see article for more reactions
The use of tetrabutylammonium fluoride (TBAF) enables a versatile approach to isoxazolines and pyrazolines by the cyclization of alkyne substrates under mild reaction conditions. A deprotection/functionalization method is described, leading to a substituted pyrazoline in good diastereoselectivity.
see article for more examples