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Palladium-Catalyzed Synthesis of 2-Aminobenzothiazoles through Tandem Reaction

Wan Xu, Meng-Tian Zeng, Min Liu, Sha-Sha Liu, Yue-Sheng Li, Zhi-Bing Dong*

*School of Chemistry and Environment Engineering, Wuhan Institute of Technology, 430074, P. R. of China, Email: dzb04982wit.edu.cn

W. Xu, M.-T. Zeng, M. Liu, S.-S. Liu, Y.-S. Li, Z.-B. Dong, Synthesis, 2017, 49, 3084-3090.

DOI: 10.1055/s-0036-1588835 (free Supporting Information)


Abstract

A tandem approach enables a facile and efficient synthesis of various 2-aminobenzothiazoles from 2-chloroanilines and dithiocarbamates in excellent yields in the presence of Pd(PPh3)4 and t-BuOK.

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Key Words

potassium tert-butoxide, palladium, chloroloanilines, aminobenzothiazoles, benzothiazoles, tandem reactions


ID: J66-Y2017