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Redox-Neutral Access to Sultams from 2-Nitrochalcones and Sulfur with Complete Atom Economy

Thanh Binh Nguyen* and Pascal Retailleau

*Institut de Chimie des Substances Naturelles, CNRS UPR 2301, Université Paris-Sud, Université Paris-Saclay, 1, avenue de la Terrasse, 91198 Gif-sur-Yvette, France, Email:

T. B. Nguyen, P. Retailleau, Org. Lett., 2017, 19, 3879-3882.

DOI: 10.1021/acs.orglett.7b01766

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A catalyst-free, redox-neutral, and completely atom-economical reaction enables the synthesis of sultams by simply heating 2-nitrochalcones with elemental sulfur in 3-picoline or N-methylmorpholine (NMM).

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proposed mechanism

Key Words


ID: J54-Y2017