Redox-Neutral Access to Sultams from 2-Nitrochalcones and Sulfur with Complete Atom Economy
Thanh Binh Nguyen* and Pascal Retailleau
*Institut de Chimie des Substances Naturelles, CNRS UPR 2301,
Université Paris-Sud, Université Paris-Saclay, 1, avenue de la Terrasse, 91198
Gif-sur-Yvette, France,
Email: nguyen
icsn.cnrs-gif.fr
T. B. Nguyen, P. Retailleau, Org. Lett., 2017, 19, 3879-3882.
DOI: 10.1021/acs.orglett.7b01766
see article for more reactions
Abstract
A catalyst-free, redox-neutral, and completely atom-economical reaction enables the synthesis of sultams by simply heating 2-nitrochalcones with elemental sulfur in 3-picoline or N-methylmorpholine (NMM).
see article for more examples
proposed mechanism
Key Words
ID: J54-Y2017
