Trifluoromethylation of Alkyl Radicals in Aqueous Solution
Haigen Shen, Zhonglin Liu, Pei Zhang, Xinqiang Tan, Zhenzhen Zhang and Chaozhong Li*
*Collaborative Innovation Center of Chemistry for Life Sciences, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China, Email: cligmail.sioc.ac.cn
H. Shen, Z. Liu, P. Zhang, X. Tan, Z. Zhang, C. Li, J. Am. Chem. Soc., 2017, 139, 9843-9846.
DOI: 10.1021/jacs.7b06044 (free Supporting Information)
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The combination of Et3SiH and K2S2O8 initiates radical reactions of primary and secondary alkyl bromides or iodides with BPyCu(CF3)3 (BPy = 2,2′-bipyridine) in aqueous acetone at room temperature to provide trifluoromethylated products in good yield. The protocol exhibits wide functional group compatibility.
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X. Tan, Z. Liu, H. Shen, P. Zhang, Z. Zhang, C. Li, J. Am. Chem. Soc., 2017, 139, 12430-12433.