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Novel One-Pot Cyclization of the Blaise Reaction Intermediate and Arylglyoxals: The Synthesis of Substituted NH-Pyrroles

Zhiwei Chen*, Hao Chen, Xiaofeng Yang, Xiangqing Chang

*College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, P. R. of China, Email: chenzhiweizjut.edu.cn

Z. Chen, H. Chen, X. Yang, X. Chang, Synlett, 2017, 28, 1463-1466.

DOI: 10.1055/s-0036-1588168 (free Supporting Information)


Abstract

The Blaise reaction intermediate, generated in situ from Reformatsky reagent and nitrile, reacts with arylglyoxals chemoselectively to afford a wide variety of substituted NH-pyrroles in good yields.

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Key Words

pyrroles, Blaise reaction, arylglyoxals, Reformatsky reagent


ID: J60-Y2017