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Cu-Catalyzed Hydrocarbonylative C-C Coupling of Terminal Alkynes with Alkyl Iodides

Li-Jie Cheng and Neal P. Mankad*

*Department of Chemistry, University of Illinois at Chicago, 845 W. Taylor Street, Chicago, Illinois 60607, United States, Email:

L.-J. Cheng, N. P. Mankad, J. Am. Chem. Soc., 2017, 139, 10200-10203.

DOI: 10.1021/jacs.7b05205


A Cu-catalyzed hydrocarbonylative C-C coupling of unactivated alkyl iodides with terminal alkynes enables a highly chemo- and regioselective synthesis of unsymmetrical dialkyl ketones. A variety of functional groups are tolerated, and both primary and secondary alkyl iodides react well.

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Key Words

ketones, PMHS, multicomponent reactions

ID: J48-Y2017