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Pd(II)/Bipyridine-Catalyzed Conjugate Addition of Arylboronic Acids to α,β-Unsaturated Carboxylic Acids. Synthesis of β-Quaternary Carbons Substituted Carboxylic Acids

Rui Liu, Zhenyu Yang, Yuxin Ni, Kaixuan Song, Kai Shen, Shaohui Lin* and Qinmin Pan*

*Chemical Engineering and Materials Science, Soochow University, 199 Ren'ai Road, Suzhou 215123, P. R. China, Email: linshaohuisuda.edu.cn, qpansuda.edu.cn

R. Liu, Z. Yang, Y. Ni, K. Song, K. Shen, S. Lin, Q. Pan, J. Org. Chem., 2017, 82, 8023-8030.

DOI: 10.1021/acs.joc.7b01248 (free Supporting Information)


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Abstract

A mild and convenient Pd(II)/bipyridine-catalyzed conjugate addition of arylboronic acids to α,β-unsaturated carboxylic acids provides β-substituted carboxylic acids including highly challenging β-quaternary carbons.

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Key Words

arylation


ID: J42-Y2017