Pd(II)/Bipyridine-Catalyzed Conjugate Addition of Arylboronic Acids to α,β-Unsaturated Carboxylic Acids. Synthesis of β-Quaternary Carbons Substituted Carboxylic Acids
Rui Liu, Zhenyu Yang, Yuxin Ni, Kaixuan Song, Kai Shen, Shaohui Lin* and Qinmin Pan*
*Chemical Engineering and Materials Science, Soochow University, 199 Ren'ai Road, Suzhou 215123, P. R. China, Email: linshaohuisuda.edu.cn, qpansuda.edu.cn
R. Liu, Z. Yang, Y. Ni, K. Song, K. Shen, S. Lin, Q. Pan, J. Org. Chem., 2017, 82, 8023-8030.
DOI: 10.1021/acs.joc.7b01248 (free Supporting Information)
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A mild and convenient Pd(II)/bipyridine-catalyzed conjugate addition of arylboronic acids to α,β-unsaturated carboxylic acids provides β-substituted carboxylic acids including highly challenging β-quaternary carbons.
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