Enantioselective Construction of Tertiary C-O Bond via Allylic Substitution of Vinylethylene Carbonates with Water and Alcohols
Ajmal Khan, Sardaraz Khan, Ijaz Khan, Can Zhao, Yuxue Mao, Yan Chen and Yong Jian Zhang*
*School of Chemistry and Chemical Engineering, and Shanghai Key Laboratory of Electrical Insulation and Thermal Aging, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, P. R. China, Email: yjiansjtu.edu.cn
A. Khan, S. Khan, I. Khan, C. Zhao, Y. Mao, Y. Chen, Y. J. Zhang, J. Am. Chem. Soc., 2017, 139, 10733-10741.
DOI: 10.1021/jacs.7b04759 (free Supporting Information)
see article for more reactions
A cooperative catalysis system of an in situ generated chiral palladium complex and a boron reagent enables an enantioselective construction of tertiary C-O bond via asymmetric allylic substitution of racemic vinylethylene carbonates with water and alcohols. Valuable tertiary alcohols and ethers are obtained in high yields with complete regioselectivities and high enantioselectivities.
see article for more examples