Palladium-Catalyzed Formylation of Aryl Iodides with HCOOH as CO Source
Guanglong Sun, Xue Lv, Yinan Zhang, Min Lei* and Lihong Hu*
*Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, P. R. China, Email: mleisimm.ac.cn, lhhusimm.ac.cn
G. Sun, X. Lv, M. Lei, L. Hu, Org. Lett., 2017, 19, 4235-4238.
DOI: 10.1021/acs.orglett.7b01882 (free Supporting Information)
A palladium-catalyzed reductive carbonylation enables a facile and practical synthesis of aromatic aldehydes from aryl iodides and HCOOH. HCOOH serves not only as convenient and environmental-friendly C1 source but also as the reviving agent in the reductive elimination process of a Pd-catalyst.
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