Palladium-Catalyzed Formylation of Aryl Iodides with HCOOH as CO Source
Guanglong Sun, Xue Lv, Yinan Zhang, Min Lei* and Lihong Hu*
*Shanghai Institute of Materia Medica, Chinese Academy of
Sciences, Shanghai 201203, School of Pharmacy, Nanjing University of Chinese
Medicine, Nanjing, P. R. China, Email: mlei
simm.ac.cn, lhhusimm.ac.cn
G. Sun, X. Lv, M. Lei, L. Hu, Org. Lett., 2017, 19, 4235-4238.
DOI: 10.1021/acs.orglett.7b01882
Abstract
A palladium-catalyzed reductive carbonylation enables a facile and practical synthesis of aromatic aldehydes from aryl iodides and HCOOH. HCOOH serves not only as convenient and environmental-friendly C1 source but also as the reviving agent in the reductive elimination process of a Pd-catalyst.
see article for more examples
proposed mechanism
Key Words
formylation, triphenylphosphine
ID: J54-Y2017
