Direct Aldehyde C-H Arylation and Alkylation via the Combination of Nickel, Hydrogen Atom Transfer, and Photoredox Catalysis
Xiaheng Zhang and David W. C. MacMillan*
*Merck Center for Catalysis at Princeton University, Princeton, New Jersey 08544, United States, Email: dmacmillprinceton.edu
X. Zhang, D. W. C. MacMillan, J. Am. Chem. Soc., 2017, 139, 11353-11356.
DOI: 10.1021/jacs.7b07078 (free Supporting Information)
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A synergistic merger of photoredox, nickel, and hydrogen atom transfer catalysis enables direct aldehyde C-H functionalization. This mild, operationally simple protocol provides a broad range of ketones in excellent yield from commercially available aldehydes, along with aryl or alkyl bromides.
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