Organic Chemistry Portal



A C-H Activation-Based Strategy for N-Amino Azaheterocycle Synthesis

Pengfei Shi, Lili Wang, Shan Guo, Kehao Chen, Jie Wang and Jin Zhu*

*School of Chemistry and Chemical Engineering, Collaborative Innovation Center of Chemistry for Life Sciences, Nanjing University, Nanjing 210023, China, Email:

P. Shi, L. Wang, S. Guo, K. Chen, J. Wang, J. Zhu, Org. Lett., 2017, 19, 4359-4362.

DOI: 10.1021/acs.orglett.7b02066

see article for more reactions


Rh(III)-catalyzed coupling of N-Boc hydrazones/N-Boc hydrazines with diazodiesters/diazoketoesters provides convenient access to synthetically and medicinally important N-amino isoquinolin-3-ones and N-amino indoles via a C-H activation-based strategy.

see article for more examples

Key Words

isoquinolin-3-ones, indoles

ID: J54-Y2017