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A C-H Activation-Based Strategy for N-Amino Azaheterocycle Synthesis

Pengfei Shi, Lili Wang, Shan Guo, Kehao Chen, Jie Wang and Jin Zhu*

*School of Chemistry and Chemical Engineering, Collaborative Innovation Center of Chemistry for Life Sciences, Nanjing University, Nanjing 210023, China, Email: jinznju.edu.cn

P. Shi, L. Wang, S. Guo, K. Chen, J. Wang, J. Zhu, Org. Lett., 2017, 19, 4359-4362.

DOI: 10.1021/acs.orglett.7b02066 (free Supporting Information)



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Abstract

Rh(III)-catalyzed coupling of N-Boc hydrazones/N-Boc hydrazines with diazodiesters/diazoketoesters provides convenient access to synthetically and medicinally important N-amino isoquinolin-3-ones and N-amino indoles via a C-H activation-based strategy.


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Key Words

isoquinolin-3-ones, indoles


ID: J54-Y2017