Manganese Catalyzed α-Olefination of Nitriles by Primary Alcohols
Subrata Chakraborty, Uttam Kumar Das, Yehoshoa Ben-David and David Milstein*
*Department of Organic Chemistry, The Weizmann Institute of
Science, Rehovot, 76100, Israel, Email: david.milstein
weizmann.ac.il
S. Chakraborty, U. K. Das, Y. Ben-David, D. Milstein, J. Am. Chem. Soc., 2017, 139, 11710-11713.
DOI: 10.1021/jacs.7b06993
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Abstract
An α-olefination of nitriles using primary alcohols, via dehydrogenative coupling of alcohols with nitriles is catalyzed by a manganese pincer complex. The reaction runs in the absence of any additives, base, or hydrogen acceptor, liberating dihydrogen and water as the only byproducts.
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proposed mechanism
Key Words
ID: J48-Y2017
