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Praseodymium(III)-Catalyzed Regioselective Synthesis of C3-N-Substituted Coumarins with Coumarins and Azides

Jiu-ling Li, Da-chao Hu, Xin-ping Liang, Ying-Chun Wang, Heng-Shan Wang* and Ying-ming Pan*

*State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmaceutical Sciences of Guangxi Normal University, Guilin 541004, People's Republic of China, Email: whengshan163.com, panymmailbox.gxnu.edu.cn

J.-l. Li, D.-c. Hu, X.-p. Liang, Y.-C. Wang, H.-S. Wang, Y.-m. Pan, J. Org. Chem., 2017, 82, 9006-9001.

DOI: 10.1021/acs.joc.7b01410


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Abstract

C3-N-substituted coumarins can be synthesized in good yields directly from coumarins and azides in the presence of Pr(OTf)3 without additives or ligands.


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proposed mechanism



Key Words

coumarins


ID: J42-Y2017