Combinatorial Nickel-Catalyzed Monofluoroalkylation of Aryl Boronic Acids with Unactivated Fluoroalkyl Iodides
Jie Sheng, Hui-Qi Ni, Ge Liu, Yan Li and Xi-Sheng Wang*
*Hefei National Laboratory for Physical Sciences at the
Microscale and Department of Chemistry, University of Science and Technology of
China, 96 Jinzhai Road, Hefei, Anhui 230026, China, Email: xswang77
ustc.edu.cn
J. Sheng, H.-Q. Ni, G. Liu, Y. Li, X.-S. Wang, Org. Lett., 2017, 19, 4440-4443.
DOI: 10.1021/acs.orglett.7b02012
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Abstract
A nickel-catalyzed cross-coupling between arylboronic acids and unactived 1-fluoro-1-iodoalkanes offers high efficiency, mild conditions, and excellent functional-group compatibility. Readily available nitrogen and phosphine ligands generated a variety of easily tunable catalysts to promote the fluoroalkylation for a broad range of both coupling partners.
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Key Words
ID: J54-Y2017
