Palladium-Catalyzed Incorporation of Two C1 Building Blocks: The Reaction of Atmospheric CO2 and Isocyanides with 2-Iodoanilines Leading to the Synthesis of Quinazoline-2,4(1H,3H)-diones
Pei Xu, Fei Wang, Tian-Qi Wei, Ling Yin, Shun-Yi Wang* and Shun-Jun Ji*
*Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Soochow University, Suzhou 215123, China, Email: shunyisuda.edu.cn, shunjunsuda.edu.cn
P. Xu, F. Wang, T.-Q. Wei, L. Yin, S.-Y. Wang, S.-J. Ji, Org. Lett., 2017, 19, 4484-4487.
DOI: 10.1021/acs.orglett.7b01877
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Abstract
A Pd-catalyzed insertion and cycloaddition of CO2 and isocyanide to 2-iodoanilines provides quinazoline-2,4(1H,3H)-diones under mild conditions through the formation of C-C, C-O, and C-N bonds.
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Key Words
quinazolinediones, multicomponent reactions
ID: J54-Y2017