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Synthesis of 3-Aryl-2-pyrones by Palladium-Catalyzed Cross-Coupling of Aryl Iodides with Cyclic Vinyldiazo Ester

Jun Huang, Linyong Li, Haoguo Chen, Tiebo Xiao, Yuwei He and Lei Zhou*

*School of Chemistry, Sun Yat-Sen University, 135 Xingang West Road, Guangzhou 510275, China, Email:

J. Huang, L. Li, H. Chen, T. Xiao, Y. He, L. Zhou, J. Org. Chem., 2017, 82, 9204-9209.

DOI: 10.1021/acs.joc.7b01470

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A palladium-catalyzed cross-coupling reaction of cyclic vinyldiazo ester with aryl iodides provides various 3-aryl-2-pyrones in good yields with high functional group tolerance. The resulting 3-aryl-2-pyrones can be used as diene components in Diels-Alder reactions.

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proposed mechanism

Key Words


ID: J42-Y2017