Transition-Metal- and Halogen-Free Oxidation of Benzylic sp3 C-H Bonds to Carbonyl Groups Using Potassium Persulfate
Yixin Hu, Lihong Zhou, Wenjun Lu*
*Department of Chemistry, Shanghai Jiao Tong University, 800
Dongchuan Road, Shanghai 200240, P. R. of China, Email: luwj
sjtu.edu.cn
Y. Hu, L. Zhou, W. Lu, Synthesis, 2017, 49, 4007-4016.
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Abstract
The use of potassium persulfate enables an aerobic oxidation of benzyl substrates to provide aryl carbonyl compounds including acetophenones, benzophenones, imides, and benzoic acids under mild conditions in the presence of pyridine. Neither transition metals nor halogens are required as additives.
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Key Words
potassium persulfate, oxygen, benzylic oxidation, transition-metal-free, halogen-free
ID: J66-Y2017
