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Transition-Metal- and Halogen-Free Oxidation of Benzylic sp3 C-H Bonds to Carbonyl Groups Using Potassium Persulfate

Yixin Hu, Lihong Zhou, Wenjun Lu*

*Department of Chemistry, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, P. R. of China, Email: luwjsjtu.edu.cn

Y. Hu, L. Zhou, W. Lu, Synthesis, 2017, 49, 4007-4016.

DOI: 10.1055/s-0036-1588429 (free Supporting Information)


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Abstract

The use of potassium persulfate enables an aerobic oxidation of benzyl substrates to provide aryl carbonyl compounds including acetophenones, benzophenones, imides, and benzoic acids under mild conditions in the presence of pyridine. Neither transition metals nor halogens are required as additives.

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Key Words

potassium persulfate, oxygen, benzylic oxidation, transition-metal-free, halogen-free


ID: J66-Y2017