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Domino-Fluorination-Protodefluorination Enables Decarboxylative Cross-Coupling of α-Oxocarboxylic Acids with Styrene via Photoredox Catalysis

Muliang Zhang, Junwei Xi, Rehanguli Ruzi, Nan Li, Zhongkai Wu, Weipeng Li and Chengjian Zhu*

*State Key Laboratory of Coordination Chemistry, Jiangsu Key Laboratory of Advanced Organic Materials, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, China, Email:

M. Zhang, J. Xi, R. Ruzi, N. Li, Z. Wu, W. Li, C. Zhu, J. Org. Chem., 2017, 82, 9305-9311.

DOI: 10.1021/acs.joc.7b01054 (free Supporting Information)

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Photoredox catalysis enables a domino-fluorination-protodefluorination decarboxylative cross-coupling of α-keto acids with styrene to provide α,β-unsaturated ketones under mild conditions.

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proposed mechanism

Key Words

enones, Selectfluor, photochemistry

ID: J42-Y2017