Domino-Fluorination-Protodefluorination Enables Decarboxylative Cross-Coupling of α-Oxocarboxylic Acids with Styrene via Photoredox Catalysis
Muliang Zhang, Junwei Xi, Rehanguli Ruzi, Nan Li, Zhongkai Wu, Weipeng Li and Chengjian Zhu*
*State Key Laboratory of Coordination Chemistry, Jiangsu Key
Laboratory of Advanced Organic Materials, School of Chemistry and Chemical
Engineering, Nanjing University, Nanjing 210093, China, Email: cjzhu
nju.edu.cn
M. Zhang, J. Xi, R. Ruzi, N. Li, Z. Wu, W. Li, C. Zhu, J. Org. Chem., 2017, 82, 9305-9311.
DOI: 10.1021/acs.joc.7b01054
see article for more reactions
Abstract
Photoredox catalysis enables a domino-fluorination-protodefluorination decarboxylative cross-coupling of α-keto acids with styrene to provide α,β-unsaturated ketones under mild conditions.
see article for more examples
proposed mechanism
Key Words
enones, Selectfluor, photochemistry
ID: J42-Y2017
