Selectivity Control in Ruthenium(II)-Catalyzed C-H/N-O Activation with Alkynyl Bromides
Huawen Huang, Sachiyo Nakanowatari and Lutz Ackermann*
*Institut für Organische und Biomolekulare Chemie, Georg-August-Universität, Tammannstraße 2, 37077 Göttingen, Germany, Email: lutz.ackermannchemie.uni-goettingen.de
H. Huang, S. Nakanowatari, L. Ackermann, Org. Lett., 2017, 19, 4620-4623.
DOI: 10.1021/acs.orglett.7b02247
Abstract
A chemoselective ruthenium(II) catalysis enabled mild reaction conditions for positional selective annulations of bromoalkynes to provide isoquinolones with organic substituents distal to nitrogen - complementary to previous protocols.
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proposed mechanism
Key Words
ID: J54-Y2017