In situ Generation and Utilization of CO: An Efficient Route towards N-Substituted Saccharin via Carbonylative Cyclization of 2-Iodosulfonamides
Sujit P. Chavan, Adithyaraj K., Bhalchandra M. Bhanage*
*Department of Chemistry, Institute of Chemical Technology,
N. Parekh Marg, Matunga, Mumbai-400019, India,
Email: bm.bhanageictmumbai.edu.in
S. P. Chavan, Adithyaraj. K., B. M. Bhanage, Synlett, 2017, 28, 2000-2003.
DOI: 10.1055/s-0036-1588422
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Abstract
A carbonylative cyclization of 2-iodosulfonamides using a Pd(OAc)2/Xantphos catalyst system and phenyl formate as a CO source provides various saccharin derivatives under milder reaction conditions.
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Key Words
carbonylative cyclization, palladium catalysis, CO surrogate, phenyl formate, N-substituted saccharin, benzo-fused N-heterocycles, benzo-fused S-heterocycles
ID: J60-Y2017