γ-Amino Butyric Acid (GABA) Synthesis Enabled by Copper-Catalyzed Carboamination of Alkenes
Nengbo Zhu, Ting Wang, Liang Ge, Yajun Li, Xinhao Zhang* and Hongli Bao*
*Peking University Shenzhen Graduate School, Shenzhen 518055;
University of Chinese Academy of Sciences, 155 Yangqiao Road West, Fuzhou,
Fujian 350002, China, Email: zhangxh
pkusz.edu.cn, hlbaofjirsm.ac.cn
N. Zhu, T. Wang, L. Ge, Y. Li, X. Zhang, H. Bao, Org. Lett., 2017, 19, 4718-4721.
DOI: 10.1021/acs.orglett.7b01969
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Abstract
Copper-catalyzed carboamination of alkenes enables an efficient synthesis of γ-amino butyric acid (GABA) derivatives from alkenes. In this difunctionalization reaction, acetonitrile serves as the source of the carbon and nitrogen functionalities. A copper-catalyzed radical-polar crossover mechanism is proposed.
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proposed mechanism
Key Words
Nitriles, Ritter Reaction, Benzoyl Peroxide
ID: J54-Y2017
