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γ-Amino Butyric Acid (GABA) Synthesis Enabled by Copper-Catalyzed Carboamination of Alkenes

Nengbo Zhu, Ting Wang, Liang Ge, Yajun Li, Xinhao Zhang* and Hongli Bao*

*Peking University Shenzhen Graduate School, Shenzhen 518055; University of Chinese Academy of Sciences, 155 Yangqiao Road West, Fuzhou, Fujian 350002, China, Email:,

N. Zhu, T. Wang, L. Ge, Y. Li, X. Zhang, H. Bao, Org. Lett., 2017, 19, 4718-4721.

DOI: 10.1021/acs.orglett.7b01969 (free Supporting Information)

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Copper-catalyzed carboamination of alkenes enables an efficient synthesis of γ-amino butyric acid (GABA) derivatives from alkenes. In this difunctionalization reaction, acetonitrile serves as the source of the carbon and nitrogen functionalities. A copper-catalyzed radical-polar crossover mechanism is proposed.

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proposed mechanism

Key Words

Nitriles, Ritter Reaction, Benzoyl Peroxide

ID: J54-Y2017