Organic Chemistry Portal

Abstracts

Search:

Synthesis of O-Aroyl-N,N-dimethylhydroxylamines through Hypervalent Iodine-Mediated Amination of Carboxylic Acids with N,N-Dimethylformamide

Chuancheng Zhang, Qiang Yue, Zhen Xiao, Xianglan Wang, Qian Zhang, Dong Li*

*School of Materials and Chemical Engineering, Hubei University of Technology, Wuhan 430068, P. R. of China, Email: donglimail.hbut.edu.cn

C. Zhang, Q. Yue, Z. Xiao, X. Wang, Q. Zhang, D. Li, Synthesis, 2017, 49, 4303-4308.

DOI: 10.1055/s-0036-1588460 (free Supporting Information)


see article for more reactions

Abstract

A hypervalent iodine mediated reaction between carboxylic acids and N,N-dimethylformamide occurs under mild conditions at room temperature to provide O-aroyl-N,N-dimethylhydroxylamines in good yields, which are important electrophilic amination reagents. The process shows good functional group compatibility and air and moisture tolerance.

see article for more examples



Key Words

benzoyl hydroxylamines, hydroxylamines, hypervalent iodine compounds, carboxylic acids, N,N-dimethylformamide, amination


ID: J66-Y2017