Palladium-Catalyzed Carbonylative Transformation of Organic Halides with Formic Acid as the Coupling Partner and CO Source: Synthesis of Carboxylic Acids
Fu-Peng Wu, Jin-Bao Peng*, Xinxin Qi and Xiao-Feng Wu*
*Zhejiang Sci-Tech University, Hangzhou, Zhejiang 310018,
People's Republic of China;
Universität Rostock, Albert-Einstein-Str. 29a, 18059 Rostock, Germany, Email:
pengjb_05
zstu.edu.cn, xiao-feng.wucatalysis.de
F.-P. Wu, J.-B. Peng, X. Qi, X.-F. Wu, J. Org. Chem., 2017, 82, 9710-9714.
DOI: 10.1021/acs.joc.7b01808
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Abstract
A palladium-catalyzed carbonylative transformation of organic halides with formic acid as the coupling partner provides carboxylic acids in the presence of a catalytic amount of DCC as the activator. Both vinyl and aryl (pseudo)halides were conveniently transformed into the corresponding acids in good yields.
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proposed mechanism
Key Words
α,β-unsaturated compounds, arenes
ID: J42-Y2017
