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Palladium-Catalyzed Carbonylative Transformation of Organic Halides with Formic Acid as the Coupling Partner and CO Source: Synthesis of Carboxylic Acids

Fu-Peng Wu, Jin-Bao Peng*, Xinxin Qi and Xiao-Feng Wu*

*Zhejiang Sci-Tech University, Hangzhou, Zhejiang 310018, People's Republic of China; Universitšt Rostock, Albert-Einstein-Str. 29a, 18059 Rostock, Germany, Email: pengjb_05zstu.edu.cn, xiao-feng.wucatalysis.de

F.-P. Wu, J.-B. Peng, X. Qi, X.-F. Wu, J. Org. Chem., 2017, 82, 9710-9714.

DOI: 10.1021/acs.joc.7b01808 (free Supporting Information)



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Abstract

A palladium-catalyzed carbonylative transformation of organic halides with formic acid as the coupling partner provides carboxylic acids in the presence of a catalytic amount of DCC as the activator. Both vinyl and aryl (pseudo)halides were conveniently transformed into the corresponding acids in good yields.

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proposed mechanism



Key Words

α,β-unsaturated compounds, arenes


ID: J42-Y2017