Iron-Catalyzed Carboamination of Olefins: Synthesis of Amines and Disubstituted β-Amino Acids
Bo Qian, Shaowei Chen, Ting Wang, Xinhao Zhang* and Hongli Bao*
*Peking University Shenzhen Graduate School, Shenzhen 518055;
University of Chinese Academy of Sciences, 155 Yangqiao Road West, Fuzhou,
Fujian 350002, China, Email: zhangxh
pkusz.edu.cn, hlbaofjirsm.ac.cn
B. Qian, S. Chen, T. Wang, X. Zhang, H. Bao, J. Am. Chem. Soc., 2017, 139, 13076-13082.
DOI: 10.1021/jacs.7b06590
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Abstract
A general alkylamination of vinylarenes and an unprecedented diastereoselective anti-carboamination of unsaturated esters provide amines and unnatural β-amino acids. This alkylamination is enabled by an iron catalyst and alkyl diacyl peroxides, that serve as both alkylating reagents and internal oxidizing agents.
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proposed mechanism
Key Words
Ritter Reaction, Alkylation, β-Amino Acids (amination, alkylation)
ID: J48-Y2017
